Mayo Leads Global Study on Breast Drug Side Effect
Updated: 2010-09-28 02:26:49
Mayo Clinic researchers and their international colleagues have discovered genetic variants that lead to severe arthritis for a subset of women when taking aromatase inhibitors to treat their breast cancer. This serious side effect is so painful that many women halt their lifesaving medication. The findings appear today in the online issue of the Journal of [...]

Multiple sclerosis patients can learn to cope better with the fatigue, depression, and anxiety that often accompany the disease, researchers said.
Maria Collazo-Clavell, M.D., expert in obesity and diabetes mellitus Speaks English and Spanish To schedule an interview, call: Media Relations Consultant Bob Nellis (507-284-5005)
What is a kidney stone?
A kidney stone is a hard, crystalline mineral material formed within the kidney or urinary tract. Kidney stones are a common cause of blood in the urine and often severe pain in the abdomen, flank, or groin. Kidney stones are sometimes called renal calculi. One in ...
Lung Cancer and EGFR
Overview
A substantial percentage of lung cancers express cell surface epidermal growth factor receptors (EGFRs). As activation of these cell surface receptors has been shown in experimental systems to result in the growth and progression of the malignancy, there have been considerable pre-clinical and clinical research efforts ...
Colorectal Cancer and KRAS
Overview
One actively investigated approach in the management of advanced and metastatic colorectal cancer (CRC) has been the delivery of agents whose primary purpose is to interfere with the biological activity of the epidermal growth factor receptor (EGFR).
However, it is well-recognized that only a subset of patients ...
Chronic Myeloid Leukemia and BCR-ABL
Overview
Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is one of the few cancers that is known to caused by a single, specific genetic mutation in more than 90% of cases.
The transformation to CML is caused by a reciprocal translocation of the BCR ...
Breast Cancer and HER2
Overview
Approximately 30% of malignant breast cancers demonstrate overamplification of the human epidermal receptor type 2 (HER2) gene, resulting in an overexpression of the HER2 receptor, a transmembrane tyrosine kinase receptor within the epidermal growth factor receptor (EGFR) family. Activation of this class of cellular receptors is ...